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Jared Shuster, LHP Braves: The Braves No. 2 prospect struck out a dozen batters over seven innings en route to his sixth win of the season. Shuster allowed just two hits and walked none, as his dominant 2022 season continued. Shuster has pitched to a 2.87 ERA over 84.2 innings with 98 strikeouts on the back of his command of his three-pitch arsenal.

Corbin Carroll, OF D-Backs: Carroll was promoted to Triple-A Reno earlier this week and has now homered in both games he’s played in at the level. Carroll hit leadoff for the Aces going 1-for-3 with a home run, three RBIs and a walk. He’ll head to the Futures Game this weekend as a member of a fearsome NL outfield.

Pete Crow-Armstrong, OF Cubs: Speaking of the NL’s fearsome outfield for the Futures Game, Pete Crow-Armstrong had a huge game on Tuesday. The outfielder went 2-for-4 with a home run, two walks and three stolen bases. This is a prime example of what Crow-Armstrong is capable of on any given night—filling up the stat sheet with power and speed while playing a standout center field.

Marcelo Mayer, SS Red Sox: In a game suspended in the fourth inning, Mayer made sure to get on base in both of his plate appearances. He homered in his first plate appearance on a line shot to left and then walked in his second. As expected Mayer is showing his advanced hit tool at the lower levels, and his bat-to-ball skills, on-base ability and power have all been on display. The Red Sox shortstop is one of the best young prospects in the game.

Jose Ramos, OF Dodgers: The Dodgers outfielder had arguably the loudest night of any prospect at the plate. Ramos went 3-for-5 with two home runs and seven runs driven in. His second home run was a grand slam as he helped Great Lakes blow it open with a nine-run inning in the top of the fifth. Ramos has shown plus power in games but it’s come with a heavy dose of swing and miss. It’s a matter of making enough contact to get to his power and so far Ramos has fallen on the positive side of that line.

Following its opening on 5 July, the 2022 session of the High-level Political Forum on Sustainable Development (HLPF) continued with consideration of progress on four out of five Goals undergoing in-depth review this year. Countries also began presentations of their voluntary national reviews (VNRs). Thematic sessions discussed local action, equal access to vaccines, work towards the 2023 SDG Summit, building back better in small island developing States (SIDS), and civil society’s perspectives.

The Report on the 10 Year Framework of Programmes on Sustainable Consumption and Production Patterns (10YFP) was also introduced.

On 6 July, governments reviewed SDG 4 (quality education). Diego Pary Rodríguez, ECOSOC Vice President, Bolivia, who chaired the session, highlighted that it would feed into the Transforming Education Summit taking place in September 2022. Leonardo Garnier, UN Secretary-General’s Special Adviser for the Transforming Education Summit, emphasized the need to “ignite a movement to transform education into a true human right for all.”

Delegates stressed the need to ensure access to quality education for all, invest in teachers, bridge the digital divide and harness the potential of e-learning, lower the cost of higher education, and better equip youth entering the job market. Others shared actions related to the promotion of nuclear science and technology, teacher training for early childhood development, inclusive education, digital and green education programmes, and education as a public good. They also shared progress towards SDG 4 in the context of the COVID-19 pandemic, with some expressing concern that setbacks would be hard to overcome due to digital divides that mostly hit low-income students and learners with disabilities.

On 7 July, SGD 5 (gender equality) and SDG 14 (life below water) underwent in-depth review.

On SDG 5, Denis Mukwege, 2018 Nobel Peace Prize Laureate, Democratic Republic of the Congo, highlighted fragile progress towards gender equality and setbacks that women’s rights faced recently. Paul Pacheco, UN Department of Economic and Social Affairs (DESA), presented highlights of the report of the UN Secretary-General on progress towards SDG 5, including that 641 million women have been subjected to physical and/or sexual violence by a partner and women made up nearly 45% of global employment losses in 2020.

Frida Ravn Rosling, Danish Youth Delegate to the UN on Democracy and Partnerships, highlighted that women’s rights, including sexual and reproductive health rights, are being abolished in different parts of the world, and called for strong legislation to promote women’s rights and for protecting those working to secure them. The Holy See called on delegates to “cherish” women’s role in the family, and expressed regret at the “overemphasis” of sexual and reproductive health in the discourse on women’s empowerment.

Delegates emphasized the need for gender mainstreaming, gender-responsive budgeting, and ensuring women’s representation at all levels of governance, and many highlighted domestic initiatives to promote gender rights. Participants warned against “weaponization” of tradition, religion, and culture that undermines women’s rights, described the negative impacts of war and displacement on women and girls, and acknowledged threats to women’s rights resulting from Russia’s war in Ukraine.

In her keynote address on SDG 14, Sylvia Earle, Marine Biologist and Explorer-in-Residence at the National Geographic Society, emphasized that we must work to build back and maintain the ocean’s biogeochemical balance, underscoring that the ocean sustains all life on Earth.

Participants highlighted: Norway’s commitments to sustainable management of oceans by 2025; the importance of enhanced cooperation at all levels; investments in innovative technologies such as plant-based fish; the Blue Transformation programme of the Food and Agriculture Organization of the UN (FAO); the efforts of the High Ambition Coalition towards a treaty on the conservation and sustainable use of marine biodiversity of areas beyond national jurisdiction (BBNJ); over 400 commitments made at the Our Ocean Conference; and that USD 1 invested in the ocean can generate USD 5 in social, health, environmental benefits.

On 11 July, countries reviewed SDG 15 (life on land). Sharing findings from the Sustainable Development Goals Report 2022, Yuxi Zhang, DESA Statistics Division, noted that forest cover continues to shrink globally, with high losses reported for Latin America and sub-Saharan Africa, and approximately 40,000 documented species facing the risk of extinction. He said agricultural expansion is driving almost 90% of global deforestation, and emphasized the need to reduce net habitat loss and transition to sustainable agriculture.

Delegates considered the need to: take a systematic approach, aligned with the Convention on Biological Diversity (CBD) and other instruments; achieve Aichi Biodiversity Target 11 on the designation of protected areas; implement a whole-of-society approach to nature-based solutions; criminalize ecocide; agree on a new, ambitious global biodiversity framework at the UN Biodiversity Conference in December, including finances to support it; and implement the Regional Agreement on Access to Information, Public Participation and Justice in Environmental Matters in Latin America and the Caribbean (Escazu Agreement). They also emphasized the need to consider the interconnectedness of all SDGs, recognize Indigenous Peoples’ rights to land, and increase climate investments in local communities.

Progress on SDG 17 (partnerships for the Goals) had been reviewed on the opening day of the HLPF.

The Earth Negotiations Bulletin (ENB) highlights that 44 countries are conducting VNRs at the 2022 HLPF, of which 11 countries are presenting for the first time, 28 for the second time, three for the third time, and two for the fourth time. On 11 July, Togo and Uruguay presented the first two VNRs. On 12 July, 12 countries – Argentina, Belarus, Eritrea, Eswatini, the Gambia, Ghana, Greece, Latvia, Mali, the Philippines, Switzerland, and United Arab Emirates (UAE) – presented their VNRs.

Meeting under the auspices of the UN Economic and Social Council (ECOSOC), the 2022 session of the HLPF runs through 15 July. It is being held under the theme, ‘Building back better from the coronavirus disease (COVID-19) while advancing the full implementation of the 2030 Agenda for Sustainable Development.’ [Earth Negotiations Bulleting Coverage of HLPF 2022]

© Reuters. FILE PHOTO: A K2 Black Panther tank manufactured by South Korea’s Hyundai Rotem is displayed at the Seoul International Aerospace & Defense Exhibition, Seoul, South Korea, October 20, 2021. REUTERS/Josh Smith

By Josh Smith

SEOUL (Reuters) – South Korea’s biggest ever arms deal will make it a major supplier of weapons flooding into Europe since the Ukraine war began, with sales to NATO-member Poland involving more than 1,600 tanks and howitzers, and nearly 50 fighter jets.

South Korean and Polish officials signed a framework agreement on Wednesday in Warsaw in a deal that Poland says is a key part of their efforts to rearm in the face of the war in Ukraine, where it has sent at least $1.7 billion in military aid.

The scale and speed of the multi-billion dollar deal caught some analysts off guard, as Poland has also been buying additional Abrams tanks from the United States and has been in a dispute with Germany over a request to obtain more Leopard tanks.

Polish Defence Minister Mariusz Blaszczak said that South Korea was the only player that could provide new weapons fast enough.

“It is extremely important that the first deliveries of howitzers and tanks will take place this year,” he said at the signing ceremony.

For the countries of NATO’s eastern flank, the prospect of cooperation with South Korea is particularly interesting, said Oskar Pietrewicz, an analyst with the Polish Institute of International Affairs (PISM).

“The war in Ukraine is a stimulus for the South Korean arms industry,” Pietrewicz, said. “The interest in South Korea’s offer may be even greater if one takes into account the huge disappointment of NATO’s Eastern Flank countries with the attitude of Germany.”

The reluctance of some other countries to act has opened this opportunity, said Ramon Pacheco Pardo, the Korea Chair at the Brussels School of Governance.

“Someone has to arm Ukraine, and South Korea is seizing this opportunity,” he said.

NO LETHAL AID

Seoul, however, isn’t ready to acknowledge the sale has anything to do with Ukraine.

A U.S. ally, South Korea’s policy is that it will not provide Ukraine with lethal aid, and has sought to avoid antagonizing Russia – both for economic reasons and the influence that Moscow can exert with North Korea.

When asked if this deal signals greater involvement in the Ukraine conflict, South Korean Foreign Minister Park Jin stressed that it was only done bilaterally with Poland.

Poland has already given Ukraine some of its AHS Krab howitzers, which are made with components from South Korea. One security source said such transfers could require Seoul’s approval.

A spokesman for South Korea’s Defense Acquisition Program Administration said it does not confirm details on individual exports approvals, and said the latest deals with Warsaw are not related to helping Ukraine, but are aimed at boosting Poland’s armed forces.

“I think that it’s partly the business opportunity but also a political gesture,” Pacheco Pardo said. “South Korea will get a hit from this in terms of its relations with Russia, so there is this political choice.”

LONG-TERM PLANS

The Export-Import Bank of Korea said the nation’s arms exports hit a record high of more than $7 billion last year, but this deal would potentially dwarf that.

Officials have not confirmed its value, but the fighter jets alone are worth around $3 billion, according to manufacturer Korea Aerospace Industries (KAI), and Poland said it is one of their most important and largest defence orders in recent years.

U.S.-based defence analyst firm Forecast International said the deal could be larger than Poland’s entire current-year defense allocation of $14.1 billion.

“It’s like all of our companies, large and small, have come together to work on one project for the whole year, so it’s massive,” said Eom Hyo-sik, a former executive at Hanwha and a retired military officer.

Blaszczak said the deal goes beyond merely “filling the gaps we have in our armed forces,” and represents a “strategic approach” including technology transfers that will see Poland build many of the South Korean weapons and cooperate with Seoul long into the future.

Among the weapons involved in the deal are variants of the K2 Black Panther tank, which is manufactured by Hyundai Rotem, and the K9 Thunder, a self-propelled howitzer which is built by Hanwha Defense.

Hanwha Defense said it plans to establish a branch in Poland to use for the expansion of European defense exports, including the K9, Redback armoured vehicles, and guided missiles.

The first stage of the deal will involve 180 tanks and 48 howitzers, with the first deliveries this year. A second stage will include more than 800 tanks and 600 howitzers, and by 2026 both will be produced in Poland, Blaszczak said.

The first FA-50 jets, which can be used for training as well as combat, will arrive by the middle of next year, he added. KAI said it will help the Polish government and companies to establish maintenance, training, and production facilities which it hopes could eventually help it sell 1,000 FA-50s globally, as well as generate interest in its next-generation KF-21 jet.

Mobile Blogging For Road Warriors

What is it that draws in individuals a lot?

Blog writing is a sort of site that allows you upload in your remarks, pointers or check out anything being reviewed in the blog site that captures your passion. It is a method for individuals to engage, question or talk about regarding a specific subject. Consider it as a little team of individuals disputing or sharing remarks concerning a specific subject.

One of the lots of factors of why blog sites are really prominent is that it is subjective as well as not goal. If you check out one blog site, you will certainly really feel like you understand the individual that composed it.

In a globe where interaction modern technology is gradually establishing, blogging is among the very best means of connecting with other individuals. Today, there are a great deal of gadgets which you can make use of to produce, keep as well as upgrade your blog sites. One kind is mobile blog writing or moblogging.

Mobile blog writing or moblogging is a kind of blogging where it indicates that you can blog on the move from a portable smart phone like your mobile phone. If you desire a person to be component of an occasion without being literally in the occasion, one excellent factor to take into consideration mobile blog writing is.

One type of mobile blog writing or moblogging is via interaction gadgets such as Bluetooth or in your very own hand top or pocket computer. There is very little distinction in between a standard blog site as well as mobile blog site or moblog, the only distinction is that in moblog, you can blog on the move.

Mobile phones are additionally really helpful for blogging. Apart from the truth that you can go online with mobile phones, you can additionally blog with it while you’re on the go.

To develop your very own mobile blog site, you ought to initially establish if your mobile phone network company can sustain on the internet browsing via the net. You must likewise identify what sort of phone assistances for this type of solution.

An additional advantage of moblogging is that if you obtain influenced to narrate or you took some wonderful images on your trip and also wish to share them to the globe, you will not need to wait till you obtain your hands on your computer system and also share your ideas as well as photos in the net. With moblogging, you can blog anytime as well as anywhere.

To make it a lot easier for you, you must initially make your blog site on your computer system. You ought to register your mobile phone number to activite mobile blog writing solutions. As well as, you can currently upload in your remarks anywhere you are with your cellphone.

With mobile blog writing, you can also profit if you are getting a certain point like a vehicle. You inform them that the images are in your blog writing website and also ask them to take an appearance at it and also inform them what they assume.

Moblogging is an extremely hassle-free method to connect with individuals as well as likewise upgrade your blog website also without being literally before a computer.

One kind is mobile blog writing or moblogging.

Mobile phones are additionally extremely valuable for blogging. Apart from the truth that you can go online with mobile phones, you can additionally blog with it while you’re on the go. You ought to register your mobile phone number to activite mobile blog writing solutions. With mobile blog writing, you can also profit if you are acquiring a specific point like a vehicle.

The authors are grateful for the support from the College of Pharmacy, University of Sulaimani, Sulaymaniyah, Iraq.

1. Hussein DM, Al juboory SB, Mahmood AA. Antibacterial evaluation with computational study of new Schiff bases derived from 7-hydroxy-4-methyl coumarin. Orient J Chem. 2017;33(2):768–782. doi:10.13005/ojc/330224

2. Kupeli Akkol E, Genc Y, Karpuz B, Sobarzo-Sanchez E, Capasso R. Coumarins and coumarin-related compounds in pharmacotherapy of cancer. Cancers. 2020;12(7):1959. doi:10.3390/cancers12071959

3. Aoife L. Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer. Curr Pharm Des. 2004;10(30):3797–3811. doi:10.2174/1381612043382693

4. Zhu -J-J, Jiang J-G. Pharmacological and nutritional effects of natural coumarins and their structure–activity relationships. Mol Nutr Food Res. 2018;62(14):1701073. doi:10.1002/mnfr.201701073

5. Kirsch G, Abdelwahab AB, Chaimbault P. Natural and synthetic coumarins with effects on inflammation. Molecules. 2016;21(10):1322. doi:10.3390/molecules21101322

6. Hassan MZ, Osman H, Ali MA, Ahsan MJ. Therapeutic potential of coumarins as antiviral agents. Eur J Med Chem. 2016;123:236–255. doi:10.1016/j.ejmech.2016.07.056

7. Thakur A, Singla R, Jaitak V. Coumarins as anticancer agents: a review on synthetic strategies, mechanism of action and SAR studies. Eur J Med Chem. 2015;101:476–495. doi:10.1016/j.ejmech.2015.07.010

8. Garro A, Pungitore C. Coumarins as potential inhibitors of DNA polymerases and reverse transcriptases. searching new antiretroviral and antitumoral drugs. Curr Drug Discov Technol. 2015;12(2):66–79. doi:10.2174/1570163812666150716111719

9. Zhang L, Xu Z. Coumarin-containing hybrids and their anticancer activities. Eur J Med Chem. 2019;181:111587. doi:10.1016/j.ejmech.2019.111587

10. Menezes JC, Diederich M. Translational role of natural coumarins and their derivatives as anticancer agents. Future Med Chem. 2019;11(9):1057–1082. doi:10.4155/fmc-2018-0375

11. Konstantina CF, Dimitra JH-L, Konstantinos EL, Demetrios NN. Natural and synthetic coumarin derivatives with anti-inflammatory/antioxidant activities. Curr Pharma Des. 2004;10(30):3813–3833. doi:10.2174/1381612043382710

12. Bansal Y, Sethi P, Bansal G. Coumarin: a potential nucleus for anti-inflammatory molecules. Medl Chem Res. 2012;22(7):3049–3060. doi:10.1007/s00044-012-0321-6

13. Gao L, Wang F, Chen Y, Li F, Han B, Liu D. The antithrombotic activity of natural and synthetic coumarins. Fitoterapia. 2021;154:104947. doi:10.1016/j.fitote.2021.104947

14. Carneiro A, Matos MJ, Uriarte E, Santana L. Trending topics on coumarin and its derivatives in 2020. Molecules. 2021;26(2):501. doi:10.3390/molecules26020501

15. Mishra S, Pandey A, Coumarin MS. An emerging antiviral agent. Heliyon. 2020;6(1):e03217. doi:10.1016/j.heliyon.2020.e03217

16. Gouda MA, Hussein BH, El-Demerdash A, et al. A review: synthesis and medicinal importance of coumarins and their analogues (Part II). Curr Bioact Compd. 2020;16(7):993–1008. doi:10.2174/1573407215666191111120604

17. Makowska A, Wolff L, Saczewski F, Bednarski PJ, Kornicka A. Synthesis and cytotoxic evaluation of benzoxazole/benzothiazole-2-imino-coumarin hybrids and their coumarin analogues as potential anticancer agents. Pharmazie. 2019;74(11):648–657. doi:10.1691/ph.2019.9664

18. Utreja D, Jain N, Sharma S. Advances in synthesis and potentially bioactive of coumarin derivatives. Curr Org Chem. 2018;22(26):2509–2536.

19. Dziduch K, Kolodziej P, Paneth A, Bogucka-Kocka A, Wujec M. Synthesis and anthelmintic activity of new thiosemicarbazide derivatives-a preliminary study. Molecules. 2020;25(12):2770. doi:10.3390/molecules25122770

20. Soucy NV. Acetophenone. Wexler P, editor. 3^rd: Academic Press; 2014:43–45.

21. Shkair A MH, Shakya A K, Raghavendra N M, Naik R R. Molecular modeling, synthesis and pharmacological evaluation of 1, 3, 4-thiadiazoles as anti-inflammatory and analgesic agents. Med Chem. 2016;12(1):90–100. doi:10.2174/1573406411666150608102236

22. Altintop MD, Can OD, Demir Ozkay U, Kaplancikli ZA. Synthesis and evaluation of new 1,3,4-thiadiazole derivatives as antinociceptive agents. Molecules. 2016;21(8):1004.

23. Hu Y, Li C-Y, Wang X-M, Yang Y-H, Zhu H-L. 1,3,4-thiadiazole: synthesis, reactions, and applications in medicinal, agricultural, and materials chemistry. Chem Rev. 2014;114(10):5572–5610. doi:10.1021/cr400131u

24. Angelova VT, Vassilev NG, Nikolova-Mladenova B, et al. Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety. Med Chem Res. 2016;25(9):2082–2092. doi:10.1007/s00044-016-1661-4

25. Nisa ZU, Akhtar T. para-aminobenzoic acid-A substrate of immense significance. Mini Rev Org Chem. 2020;17(6):686–700. doi:10.2174/1570193X16666190828201234

26. Eswayah A, Khaliel S, Saad S, et al. Synthesis and analgesic activity evaluation of some new benzimidazole derivatives. AASCIT. 2017;4(5):30–35.

27. Antonijevic MR, Simijonovic DM, Avdovic EH, et al. Green one-pot synthesis of coumarin-hydroxybenzohydrazide hybrids and their antioxidant potency. Antioxidants. 2021;10(7). doi:10.3390/antiox10071106

28. Kotali A, Nasiopoulou DA, Tsoleridis CA, Harris PA, Kontogiorgis CA, Hadjipavlou-Litina DJ. Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins. Molecules. 2016;21(2):138. doi:10.3390/molecules21020138

29. Guo H, Callaway JB, Ting JP-Y. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21(7):677–687. doi:10.1038/nm.3893

30. Michels da Silva D, Langer H, Graf T. Inflammatory and molecular pathways in heart failure-ischemia, HFpEF and transthyretin cardiac amyloidosis. Int J Mol Sci. 2019;20(9):2322. doi:10.3390/ijms20092322

31. Zhang X, Wu X, Hu Q, et al. Mitochondrial DNA in liver inflammation and oxidative stress. Life Sci. 2019;236:116464. doi:10.1016/j.lfs.2019.05.020

32. Fritsch J, Abreu MT. The microbiota and the immune response: what is the chicken and what is the egg? Gastrointestinal Endosc Clin N Am. 2019;29(3):381–393. doi:10.1016/j.giec.2019.02.005

33. Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective. Biochem Pharmacol. 2020;180:114147. doi:10.1016/j.bcp.2020.114147

34. Gupta AK, Pandey J, Synthesis AA. Evaluation of some new 2-(5-(4-Benzamidobenzylidene)-2,4dioxothiazolidin-3-Yl) acetic acid analogs as aldose reductase inhibitors. Asian J Pharm Clin Res. 2016;10(1):62. doi:10.22159/ajpcr.2017.v10i1.12073

35. Budoff PW. Use of mefenamic acid in the treatment of primary dysmenorrhea. JAMA. 1979;241(25):2713–2716. doi:10.1001/jama.1979.03290510021018

36. Kowalski ML, Makowska JS. Seven steps to the diagnosis of NSAIDs hypersensitivity: how to apply a new classification in real practice? Allergy Asthma Immunol Res. 2015;7(4):312–320. doi:10.4168/aair.2015.7.4.312

37. Tacconelli S, Bruno A, Grande R, Ballerini P, Patrignani P. Nonsteroidal anti-inflammatory drugs and cardiovascular safety – translating pharmacological data into clinical readouts. Expert Opin Drug Saf. 2017;16(7):791–807. doi:10.1080/14740338.2017.1338272

38. Li J, Yin Y, Wang L, et al. Synthesis, characterization, and anti-inflammatory activities of methyl salicylate derivatives bearing piperazine moiety. Molecules. 2016;21(11):1544. doi:10.3390/molecules21111544

39. Dreischulte T, Morales DR, Bell S, Guthrie B. Combined use of nonsteroidal anti-inflammatory drugs with diuretics and/or renin–angiotensin system inhibitors in the community increases the risk of acute kidney injury. Kidney Int. 2015;88(2):396–403. doi:10.1038/ki.2015.101

40. Arfè A, Scotti L, Varas-Lorenzo C, et al. Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study. BMJ. 2016;354:i4857. doi:10.1136/bmj.i4857

41. James DS. The multisystem adverse effects of NSAID therapy. J Osteopath Med. 1999;99(11):1–7.

42. García-Rayado G, Navarro M, Lanas A. NSAID induced gastrointestinal damage and designing GI-sparing NSAIDs. Expert Rev Clin Pharmacol. 2018;11(10):1031–1043. doi:10.1080/17512433.2018.1516143

43. Ilango K, Valentina P, Kumar G, Dixit D, Nilewar S, Kathiravan M. Design, synthesis and QSAR studies on a series of 2, 5-Disubstituted- 1,3,4-oxadiazole derivatives of diclofenac and naproxen for analgesic and anti-inflammatory activity. Med Chem. 2015;11(8):753–763. doi:10.2174/1573406411666150519112037

44. Arora M, Choudhary S, Singh PK, Sapra B, Silakari O. Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: a review. Life Sci. 2020;251:117631. doi:10.1016/j.lfs.2020.117631

45. Schjerning A-M, McGettigan P, Gislason G. Cardiovascular effects and safety of (non-aspirin) NSAIDs. Nat Rev Cardiol. 2020;17(9):574–584. doi:10.1038/s41569-020-0366-z

46. Lichtenstein DR, Wolfe MM. COX-2–selective NSAIDs: new and improved? JAMA. 2000;284(10):1297–1299. doi:10.1001/jama.284.10.1297

47. Sharma V, Bhatia P, Alam O, et al. Recent advancement in the discovery and development of COX-2 inhibitors: insight into biological activities and SAR studies (2008–2019). Bioorg Chem. 2019;89:103007. doi:10.1016/j.bioorg.2019.103007

48. Wallace JL. NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies. Br J Pharmacol. 2012;165(1):67–74. doi:10.1111/j.1476-5381.2011.01509.x

49. Bakhriansyah M, Souverein PC, de Boer A, Klungel OH. Gastrointestinal toxicity among patients taking selective COX‐2 inhibitors or conventional NSAIDs, alone or combined with proton pump inhibitors: a case–control study. Pharmacoepidemiol Drug Saf. 2017;26(10):1141–1148. doi:10.1002/pds.4183

50. Suthar SK, Sharma M. Recent developments in chimeric NSAIDs as safer anti‐inflammatory agents. Med Res Rev. 2015;35(2):341–407. doi:10.1002/med.21331

51. Lin X-H, Young S-H, Luo J-C, et al. Risk factors for upper gastrointestinal bleeding in patients taking selective COX-2 inhibitors: a Nationwide population-based cohort study. Pain Med. 2018;19(2):225–231. doi:10.1093/pm/pnx097

52. Baothman BK, Smith J, Kay LJ, Suvarna SK, Peachell PT. Prostaglandin D2 generation from human lung mast cells is catalysed exclusively by cyclooxygenase-1. Eur J Pharmacol. 2018;819:225–232. doi:10.1016/j.ejphar.2017.12.005

53. Daham K, Song WL, Lawson J, et al. Effects of celecoxib on major prostaglandins in asthma. Clin Exp Allergy. 2011;41(1):36–45. doi:10.1111/j.1365-2222.2010.03617.x

54. Wallace JL, Bak A, McKnight W, Asfaha S, Sharkey KA, MacNaughton WK. Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity. Gastroenterology. 1998;115(1):101–109. doi:10.1016/S0016-5085(98)70370-1

55. Chen M, Boilard E, Nigrovic PA, et al. Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody‐driven K/BxN serum–transfer arthritis. Arthritis Rheumatol. 2008;58(5):1354–1365. doi:10.1002/art.23453

56. Peesa JP, Yalavarthi PR, Rasheed A, Mandava VBR. A perspective review on role of novel NSAID prodrugs in the management of acute inflammation. J Acute Dis. 2016;5(5):364–381. doi:10.1016/j.joad.2016.08.002

57. Benbow T, Campbell J. Microemulsions as transdermal drug delivery systems for nonsteroidal anti-inflammatory drugs (NSAIDs): a literature review. Drug Dev Ind Pharm. 2019;45(12):1849–1855. doi:10.1080/03639045.2019.1680996

58. Domper Arnal M-J, Hijos-Mallada G, Lanas A. Gastrointestinal and cardiovascular adverse events associated with NSAIDs. Expert Opin Drug Saf. 2022;21(3):373–384. doi:10.1080/14740338.2021.1965988

59. Husain A, Khan M, Hasan S, Alam M. 2-Arylidene-4-(4-phenoxy-phenyl) but-3-en-4-olides: synthesis, reactions and biological activity. Eur J Med Chem. 2005;40(12):1394–1404. doi:10.1016/j.ejmech.2005.03.012

60. Adams S. An interview with Stewart Adams. Trends Pharmacol Sci. 2012;33(1):1–2.

61. BBC N. Ibuprofen: dr Stewart Adams who helped discover drug dies at 95. BBC; 2019. Available from: https://www.bbc.com/news/uk-england-nottinghamshire-47073913. Accessed January 31, 2019.

62. Varrassi G, Pergolizzi JV, Dowling P, Paladini A. Ibuprofen safety at the golden anniversary: are all NSAIDs the same? A narrative review. Adv Ther. 2020;37(1):61–82. doi:10.1007/s12325-019-01144-9

63. Salih T, Salih HA. In silico design and molecular docking studies of carbapenem analogues targeting acinetobacter baumannii PBP1A receptor. AJPS. 2020;20(3):35–50. doi:10.32947/ajps.v20i3.759

64. Swain M. chemicalize.org. J Chem Inf Model. 2012;52(2):613–615. doi:10.1021/ci300046g

65. Berman H, Henrick K, Nakamura H. Announcing the worldwide Protein Data Bank. Nat Struct Mol Biol. 2003;10(12):980. doi:10.1038/nsb1203-980

66. Orlando BJ, Lucido MJ, Malkowski MG. The structure of ibuprofen bound to cyclooxygenase-2. J Struct Biol. 2015;189(1):62–66. doi:10.1016/j.jsb.2014.11.005

67. Pacheco AB, Hpc L. Introduction to AutoDock and AutoDock Tools. Baton Rouge: Louisiana State University; 2012.

68. ChemAxon. Marvinsketch, Version 20.16. ChemAxon Ltd. Budapest, Hungary; 2020.

69. Gouthami K, Veeraraghavan V, Nagaraja P. In-silico characterization of phytochemicals identified from Vitex negundo (L) extract as potential therapy for Wnt-signaling proteins. Egypt J Med Hum Genet. 2022;23(1). doi:10.1186/s43042-022-00219-7

70. Hobani Y, Jerah A, Bidwai A. A comparative molecular docking study of curcumin and methotrexate to dihydrofolate reductase. Bioinformation. 2017;13(3):63. doi:10.6026/97320630013063

71. Morris GM, Huey R, Olson AJ. Using AUTODOCK for ligand-receptor docking. Curr Protoc Bioinform. 2008;24(1):8–14. doi:10.1002/0471250953.bi0814s24

72. Morris GM, Huey R, Lindstrom W, et al. AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem. 2009;30(16):2785–2791. doi:10.1002/jcc.21256

73. Huey R, Morris GM, Forli S. Using AutoDock 4 and AutoDock vina with AutoDockTools: a tutorial. Scripps Res Inst Mol Graph Lab. 2012;10550:92037.

74. Sobell MG. A Practical Guide to Ubuntu Linux. Pearson Education; 2015.

75. Pettersen EF, Goddard TD, Huang CC, et al. UCSF chimera – A visualization system for exploratory research and analysis. J Comput Chem. 2004;25(13):1605–1612. doi:10.1002/jcc.20084

76. Laskowski RA, Swindells MB LigPlot+: multiple ligand–protein interaction diagrams for drug discovery. ACS Publications; 2011.

77. Sinha D, Tiwari AK, Singh S, et al. Synthesis, characterization and biological activity of Schiff base analogues of indole-3-carboxaldehyde. Eur J Med Chem. 2008;43(1):160–165. doi:10.1016/j.ejmech.2007.03.022

78. Gunathilake K, Ranaweera K, Rupasinghe HPV. In vitro anti-inflammatory properties of selected green leafy vegetables. Biomedicines. 2018;6(4):107. doi:10.3390/biomedicines6040107

79. Sakat S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Int J Pharm Pharm Sci. 2010;2(1):146–155.

80. Mizushima Y, Kobayashi M. Interaction of anti-inflammatory drugs with serum proteins, especially with some biologically active proteins. J Pharm Pharmacol. 2011;20(3):169–173. doi:10.1111/j.2042-7158.1968.tb09718.x

81. Sehajpal S, Prasad DN, Singh RK. Prodrugs of non-steroidal anti-inflammatory drugs (NSAIDs): a long march towards synthesis of safer NSAIDs. Mini Rev Med Chem. 2018;18(14):1199–1219. doi:10.2174/1389557518666180330112416

82. Chmiel T, Mieszkowska A, Kempińska-Kupczyk D, Kot-Wasik A, Namieśnik J, Mazerska Z. The impact of lipophilicity on environmental processes, drug delivery and bioavailability of food components. Microchemical J. 2019;146:393–406. doi:10.1016/j.microc.2019.01.030

83. Osman NI, Sidik NJ, Awal A, Adam NA, Rezali NI. In vitro xanthine oxidase and albumin denaturation inhibition assay of Barringtonia racemosa L. and total phenolic content analysis for potential anti-inflammatory use in gouty arthritis. J Intercult Ethnopharmacol. 2016;5(4):343–349. doi:10.5455/jice.20160731025522

84. Moore DS, Notz W, Fligner MA The basic practice of statistics. W.H. Freeman and Company; 2013. Available from: https://books.google.iq/books?id=aw61ygAACAAJ. Accessed July 1, 2022.

Want to prepare vegetables for kids that they’ll actually eat? These kid-friendly vegetable recipes are healthy, quick and easy. Serve them as a side dish for dinner or for a healthy snack!

Hi friends!

Let’s talk about vegetables for kids. If you’re a parent, you’ve probably struggled to find vegetable recipes for kids…ie vegetables kids like and vegetables kids will eat! If you’re tired of serving vegetables that get thrown away, I hope this post will spark some ideas for you. 

We all know vegetables are important. They offer a wide variety of vitamins, minerals and other nutrients. But when you find a veggie your kid will eat, it’s easy to fall into the habit of serving that and only that…because it’s easier than fighting with them to try something new or dealing with them spitting it out all over the place. But it’s so important to expose young kiddos to a wide variety of foods and flavors. My goal is always to try to serve them twice a day whether it’s at meals or snacks. Does that always happen? No. But I try!

To help myself out (and you!) I rounded up some kid-friendly veggie recipes that I’m looking forward to trying, plus a few of my favs from the blog. Hopefully you see something that sparks some new vegetable ideas for kids!

Vegetable Recipes For Kids

My kids love french fries. And while he certainly prefers regular french fries or sweet potato fries, the similar shape and the crunchy coating on these green bean fries are sometimes enough to get him to eat a few. When in doubt, add ketchup. Added bonus- they’re fun for kids to help make!

Green Bean Fries via The Lean Green Bean

Kids like fun food. Kabobs are fun. Added bonus – they’ll love helping you assemble these, which makes it more likely they’ll eat a few veggies along the way!

Rainbow Veggie Kabobs via Two Healthy Kitchens

Add some extra flavor to the veggies with a marinade. It’ll make them taste less veggie-like, which kids will love! If your kids don’t like steamed veggies, try serving them raw in a salad like this! They may like the crunch!

Marinated Vegetable Salad via Iowa Girl Eats

These can cook all day in the crockpot and be ready to serve when you get home!

Slow Cooker Mashed Potatoes via Baked By Rachel

Finger foods are fun! These balls are easy to make and if you serve them with a tasty dip, the kids just might look past the green color!

Easy Spinach Balls via The Lean Green Bean

Kids like sweet. Most vegetables are not sweet. Caramelizing veggies adds a sweetness factor that will up their chances of being consumed!

Caramelized Butternut Squash via Yummy Healthy Easy

When all other veggies fail, try sweet potatoes. Especially this way. They’re hard to resist.

Melting Sweet Potatoes via Dessert For Two

Roasting carrots brings out their natural sweetness, which is enhanced with a little extra maple syrup. Pair that with bacon, which everyone loves, and these won’t last long on their plate!

Maple Bacon Roasted Carrots via The Lean Green Bean

Almost all kids love pizza! Swap the crust for some zucchini rounds, top with sauce, cheese and pepperoni for a home run!

Broiled Zucchini Pizza via Kalyn’s Kitchen

Do they typically turn their nose up at things like broccoli? These nuggets can be dipped in bbq sauce, ketcup, etc which usually helps!

Veggie Nuggets via Real Mom Nutrition

Did any of these ideas catch your eye? Pin this post to try them soon!

Kid-Friendly Vegetable Recipes

Does your kiddo have a favorite veggie recipe? Leave it in the comments!

Enjoy!
–Lindsay–

Get my free Table Talk email series where I share bite-sized nutrition information about carbs, protein, and fat, plus bonus information about snacks and sugar!

The 22 times grand slam winner Nadal is set to be last in action today on Centre Court where he will take on the No.1 Dutch men’s single-player Botic van de Zandschulp.

Plus the 2019 champion Halep will battle it out for the women’s singles against No4 seed Paula Badosa. 

Whilst Kyrgios will Americain professional Brandon Nakashima on Centre Court later today. 

So you don’t miss out on any of the action we’ve got all the information you need to know for today’s order of play. 

Wimbledon Order of Play Day 8:

Centre Court (Starting from 1.30pm)

Brandon Nakashima (USA) vs Nick Kyrgios (AUS)

Paula Badosa (ESP) vs Simona Halep (ROU)

Botic van de Zandschulp (NED) vs Rafael Nadal (ESP)

No.1 Court (Starting 1pm)

Elena Rybakina (KAZ) vs Petra Martic (CRO)

Jason Kubler (AUS) vs Taylor Fritz (USA)

Armanda Anisimova (USA) vs Harmony Tan (FRA)

No.2 Court (Starting from 11am)

Cristian Garin (CHI) vs Alex de Minaur (AUS)

Alize Cornet (FRA) vs Ajla Tomljanovic (AUS)

Yifan Xu and Zhaoxuan Yang (CHN) vs Alexa Guarachi (CHI) and Andreja Klepac (SLO)

Jack Stock and Coco Gauff (USA) vs Edouard Rodger-Vasselin and Alize Cornet (FRA)

No.3 Court (Starting from 11am)

Harriet Dart and Heather Watson (GBR) vs Lyumyla Kichenok (UKR) and Jelena Ostapenko (LAT)

Jamie Murray (GBR) and Bruno Soares (BRA) vs John Peers (AUS) and Filip Polasek (SVK)

Robert Farah (COL) and Jelena Ostapenko (LAT) vs Nikola Cacic and Aleksandra Krunic (SRB)

Mate Pavic (CRO) and Sania Mirza (IND) vs John Peers (AUS) and Gabriela Dabrowski (CAN)

Court 12 (Starting form 11am)

Alicja Rosolska (POL) and Erin Routliffe (NZL) vs Asia Muhammad (USA) and Ena Shibahara (JPN)

Jonny O’Mara and Kenneth Skupski (GBR) vs Kevin Krawietz and Andreas Mies (GER)

Mingge Xu (GBR) vs Lucia Peyre (ARG)

Court 18 (Starting from 11am)

Ella McDonald (GBR) vs Victoria Mboko (CAN)

Wesley Koolhof (NED) and Neal Skupski (GBR) vs Matthew Ebden and Max Purcell (AUS)

Talia Neilson Gatenby (GBR) vs Annabelle Xu (CAN)

Jean-Julien Rojer (NED) and Ena Shibahara (JPN ) vs Matthew Ebden and Samantha Stosur (AUS)

Court 4 (Starting at 11am)

Rose Marie Nijkamp (NED) vs Giorgia Pedone (ITA)

Edas Butvilas (LTU) and Mili Poljicak (CRO) vs Louis Bowden and Matthew Rankin (GBR)

Jack Loutit (NZL) and Edward Winter (AUS) vs Patrick Brady and William Jansen (GBR)

Liv Hovde (USA) v Anastasiya Lopata (UKR)

Court 5 (Starting 11am)

Weronika Ewald (POL) vs Nikola Bartunkova (CZE)

Hugo Coquelin and Phoenix Weir (GBR) vs Alessio Basile (BEL) and Peter Privara (SVK)

Irina Balus (SVK) vs Kayla Cross (CAN)

Luca Pow and Henry Searle (GBR) vs Tanapatt Nirundorn (THA) and Jaden Weekes (CAN)

Court 6 (Starting from 11am)

Nishesh Basavareddy (USA) and Rodrigo Pacheco Mendez (MEX) vs Coleman Wong (HKG)and Michael Zheng (USA)

Sayaka Ishii (JPN) vs Ella Seidel (GER)

Jonah Braswell (USA) and Dino Prizmic (CRO) vs Gilles Arnaud Bailly  (BEL) and Jakub Nicod (CZE)

Luca Udvardy (HUN) vs Alexis Blokhina (USA)

Court 7 (Starting from 11am)

Alexander Blockx (BEL) and Leanid Boika (USA) vs Dylan Dietrich and Kilian Feldbausch (SUI)

Joao Fonseca (BRA) and Juan Carlos Prado Angelo (BOL) vs Gonzalo Bueno and Ignacio Buse (PER)

Yu-Yun Li (TPE) vs Taylah Preston (AUS)

Peter Nad (SVK) and Martyn Pawelski (POL) vs Mika Brunold (SUI) and Nicholas Godsick (USA)

Court 8 (Starting from 11am)

Johanna Svendsen (DEN) vs Olivia Lincer (POL)

Mia Kupres (CAN) vs Celine Naef (SUI)

Gerard Campana Lee (KOR) and Jeremy Jin (AUS) vs Aidan Kim and Cooper Williams (USA)

Nikola Daubnerova (SVK) v Isabella Kruger (RSA)

Court 14 (Starting from 1pm)

Santiago Gonzalez (MEX) and Andres Molteni (ARG) vs Denis Kudla and Jack Sock (USA)

Jasmine Conway (GBR) vs Ela Nala Milic (SLO)

Matej Dodig (CRO) and Borys Zgola (POL) vs Gabriel Debru and Paul Inchauspe (FRA)

Linda Klimovicova (CZE) vs Isabelle Lacy (GBR)

Elise Mertens (BEL) and Shuai Zhang (CHN) vs Nadiia Kichenok (UKR) and Raluca Olaru (ROU)

Qavia Lopez (USA) vs Hayu Kinoshita (JPN)

Connor Henry Van Schalkwyk  (NAM) and Martin Antonio Vergara Del Puerto (PAR) vs Sebastian Gorzny and Alex Michelsen (USA)

Court 17 (Starting from 11am)

Martin Landaluce and Pedro Rodenas (ESP) vs Juan Manuel La Sernaand Lautaro Midon (ARG)

Alexander Frusina (USA) and Hayden Jones (AUS) vs Ozan Colak and Learner Tien (USA)

Lennon Roark Jones and Hayato Matsuoka (JPN) vs Jakub Mensik (CZE) and Olaf Pieczkowski (POL)

Bor Artnak (SLO) and Hynek Barton (CZE) v Paul Barbier Gazeu and Arthur Gea (FRA)

What time does Wimbledon start?

Coverage for Day 8 of Wimbledon starts at 11am with BBC 2 hosting the live sporting event all today until 7pm. 

What time does Wimbledon finish? 

The last matches of the day starts at 5.30pm with a scheudled end time of 7pm but as we all know tennis matches can go on longer than expected. 

10 MINUTE RECIPES | TASTY & CHEAP EASY MEAL IDEAS | WHAT’S FOR DINNER? | LET’S GET COOKING! Life is busy and …