Carmen Pacheco: A Journey of Perseverance and Triumph

Carmen Pacheco: A Journey of Perseverance and Triumph

Introduction:
Carmen Pacheco, a remarkable individual whose life story is one of perseverance and triumph, has left an indelible mark on the world through her unwavering determination, resilience, and commitment to making a difference. Born on July 10, 1955, in the vibrant city of Buenos Aires, Argentina, Carmen’s journey has been a testament to the power of resilience in overcoming adversity. From humble beginnings to becoming a beacon of hope for countless individuals around the globe, Carmen’s life is a testament to the human spirit’s ability to rise above any challenge. In this comprehensive biography, we delve deep into Carmen Pacheco’s life and explore the defining moments that shaped her into an inspiring figure.

Chapter 1: Early Life and Challenges
Carmen Pacheco’s early life was marked by numerous challenges that would have deterred many from pursuing their dreams. Growing up in a working-class neighborhood in Buenos Aires during a time of political and economic turmoil presented its fair share of obstacles. Despite these challenging circumstances, Carmen possessed an unwavering spirit and an insatiable thirst for knowledge.

Carmen’s parents recognized her potential from an early age and encouraged her curiosity by providing her with books and educational resources. They instilled within her the importance of education as a means to break free from the cycle of poverty that had plagued their family for generations.

However, tragedy struck when Carmen lost both her parents at the tender age of 13 due to a devastating car accident. This unforeseen event left Carmen orphaned and facing an uncertain future. Nevertheless, even amidst unimaginable grief, she refused to succumb to despair.

Chapter 2: Pursuit of Education
Determined not to let adversity define her future, Carmen channeled her grief into pursuing education as a means to carve out a better life for herself. With the support of her extended family, she enrolled in a local school and threw herself into her studies with unparalleled dedication.

Carmen’s academic prowess soon caught the attention of her teachers, who recognized her exceptional abilities. Despite facing financial constraints, Carmen’s determination led her to secure scholarships that allowed her to continue her education at prestigious institutions.

During this period, Carmen developed a deep passion for literature and social justice. She found solace in the works of renowned authors such as Gabriel Garcia Marquez and Isabel Allende, whose stories fueled her desire to make a positive impact on society. This newfound passion became the driving force behind Carmen’s relentless pursuit of knowledge.

Chapter 3: Activism and Humanitarian Efforts
Inspired by the injustices she witnessed in her community, Carmen embarked on a path of activism and humanitarian work. Her tireless efforts led to significant improvements in access to education, healthcare, and social welfare for marginalized communities.

Carmen founded several non-profit organizations dedicated to empowering underprivileged youth through education. Through these initiatives, she provided scholarships, mentoring programs, and vocational training opportunities to countless individuals who would have otherwise been denied access to quality education.

Additionally, Carmen spearheaded campaigns advocating for gender equality and women’s rights. She firmly believed that empowering women was crucial for societal progress. Her advocacy work led to legislative changes that protected women from domestic violence and ensured equal opportunities in employment.

Chapter 4: Global Impact
Carmen’s impact transcended borders as she dedicated herself to addressing global issues such as poverty alleviation and environmental conservation. Recognizing the interconnectedness of these challenges, she worked tirelessly to raise awareness about sustainable development practices and fostered collaborations between governments, NGOs, and corporations.

As an influential figure in international forums on sustainable development, Carmen played a pivotal role in shaping policies that prioritized environmental preservation while promoting economic growth. Her efforts earned her numerous accolades, including the prestigious Global Humanitarian Award.

Chapter 5: Legacy and Continued Inspiration
Carmen Pacheco’s journey of perseverance and triumph continues to inspire countless individuals worldwide. Her unwavering commitment to social justice, education, and sustainability serves as a reminder that one person can make a significant difference in the world.

In recognition of her extraordinary contributions, Carmen established the Carmen Pacheco Foundation, which continues her legacy by supporting initiatives that empower marginalized communities and promote sustainable development. The foundation provides scholarships, grants, and resources to individuals and organizations committed to creating positive change in their communities.

Conclusion:
Carmen Pacheco’s life is a testament to the transformative power of perseverance and determination. From her humble beginnings in Buenos Aires to becoming a global advocate for social justice and sustainable development, Carmen has left an indelible mark on the world. Her unwavering commitment to making a difference serves as an inspiration for generations to come. Through her remarkable journey of perseverance and triumph, Carmen Pacheco has shown us that with resilience and determination, anything is possible.

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Fantastic Four: Reckoning War Alpha #1 Review: A Marvel Comics Event 17 Years in the Making

A lot of planning goes into comic book events, with creators often spending years plotting the stories and figuring out just how many different characters need to be included. Few of these events, however, have been in the works quite as long as Marvel’s upcoming Reckoning War. Writer Dan Slott is bringing chaos to his Fantastic Four run with Fantastic Four: Reckoning War Alpha #1, a kickoff to an event that he has quite literally been planning and writing for the last 17 years. The first seeds for the Reckoning War were planted in the third issue of Slott’s She-Hulk run, and the writer has been continuing to plant them in almost every series he has worked on since. The plan is finally coming to fruition in the Fantastic Four and Reckoning War is off to a decent start here.

Reckoning War Alpha #1, written by Slott and illustrated by Carlos Pacheco, Rafael Fonteriz, and Carlos Magno, sets the stage for the event, gathering all of the players and offering readers the pitch. The long and short of the story is that the Watchers (a group of characters that are relentlessly difficult to make compelling) didn’t always have a vow not to interfere with life in the universe. They originally tried to foster growth and evolution, only for the first civilization they helped to use Watcher technology for destructive purposes. This group, which comes to be known as the Reckoning, was walled off into their own corner of the universe by the Watchers, where they were left to die. Spoiler alert: They didn’t.

The Reckoning return with a vengeance and their master plan begins with the destruction of the actual moon, likely killing Uatu and sending the world into absolute chaos. This is how the First Family and other important characters get involved. It should come as no surprise that both She-Hulk and Spider-Man are set up for pretty significant roles. The Fantastic Four, however, are the most important to the story, with Reed developing an exciting (and terrifying) connection to the Watchers in the third act. 

So much of what has happened throughout Slott’s run on Fantastic Four to this point seems like it is going to have significant importance in Reckoning War, making it a great payoff to what has been a good overall series. That said, Reckoning War has a lot going on. The story the Watchers and the Reckoning alone is a lot to process, then 39 issues of Fantastic Four are being added to the mix, alongside a She-Hulk story from nearly two decades ago. Then toss in a confusing side plot with Silver Surfer, just for good measure.

Reckoning War Alpha #1 is a solid comic book, and utilizing multiple art styles feels necessary when juggling the different stories. In spite of that quality, the issue has moments where Reckoning War already starts to feel like a bit of a chore. The first issue does a good job with the narrative balancing act, keeping you invested from page to page. The key to a great event kickoff book, though, is its ability to excite you about what’s to come, to get you hooked into the promise of an epic tale. Reckoning War‘s debut issue doesn’t fully accomplish that. 

Perhaps 17 years of planning one event is a little too much time. It’s clear that Slott is passionate about the tale, and that offers reason to be excited about what’s to come. But almost two decades of teasing and clue-dropping might have piled too much on the plate. The challenge now is going to be incorporating all of the various threads and finding a way for them to matter without getting bogged down by exposition, callbacks, and needless details. Reckoning War Alpha offers reason to believe either outcome could be true.

Published by Marvel Comics

On February 2, 2022

Written by Dan Slott

Art by Carlos Pacheco, Rafael Fonteriz, and Carlos Magno

Cover by Carlos Pacheco, Rafael Fonteriz, and Marte Gracia

The eccentric pioneers of vegetable electricity

There’s a good chance you’re familiar with Frankenstein’s monster. But have you heard about his garden?

Around the time the scientist who inspired Mary Shelley’s novel Frankenstein was busy electrocuting live animals and dead prisoners, several of his contemporaries were doing the same to perennials and root vegetables. And just as these 18th Century forays into electrical stimulation purported to make the human body more robust (by delivering it from maladies ranging from paralysis and depression to diarrhoea and venereal disease), they were also being investigated for the betterment of plant life. Experiments on electrified gardens were alleged to produce a range of benefits, from brighter flowers to tastier fruit. Before long, this pursuit went the way of its cousin, medical electro-quackery, and by the end of the 19th Century, respectable science had largely jettisoned both.

More than a century on, better tools and new insights are reanimating the study of electricity’s effects on biology. Uninformed early animal experiments have resolved over the past 200 years into real understanding – and led to promising electrical medicine. Similarly, the old vegetable experiments are being exhumed to see what modern fruit they may yield. Maybe the new understanding could even improve 21st Century gardens.

The first hints that electric shocks might have a dramatic impact on crops came not from any human intervention but from nature itself. After a lightning storm, according to longstanding Japanese farming lore, mushrooms would proliferate madly.

But you couldn’t exactly call down lightning on demand to confirm this experimentally. Until, that is, the 1740s when various new devices allowed scientists to store and deploy this still-mysterious phenomena of “electricity” at will for the first time. 

Soon deploying electricity as a gardening aid became a hot topic. Pierre Bertholon de Saint-Lazare – a French physicist and philosopher who experimented widely on the still poorly understood mysteries of electricity – curated many of his contemporaries’ plant experiments into a collection, De L’électricité des Végétaux.

Alongside the brighter blossoms, flowers were alleged to bloom earlier after electrification; similarly, electrifying fruit reportedly hastened the ripeness of their smell and taste. But Bertholon’s main focus was on the new device he had invented: instead of zapping individual fruits and vegetables one by one, the huge contraption could infuse electricity into entire garden plots. It electrified the very soil and air that nurtured the growing plants – as if it was an electrical “manure”.

The electro-vegeto-meter

The elevated system of masts and wiring Bertholon had rigged up collected atmospheric electricity, drew it down, and distributed it into his crops. According to him, it mimicked the stimulating effects of lightning. Only it did the job better than the natural variety, dispensing small, continuous amounts of electricity rather than dosing with a single, damaging strike. The “electro-vegeto-meter”, he reported, increased the growth of the plants beneath its arc, accelerating “the germination, the growth, and production of leaves, flowers, fruit, and their multiplication”.

Bertholon also made copious use of electricity in other forms, reportedly dispatching insect pests by using a rudimentary tool to zap an infested tree. His contemporaries had many other colourful uses for electricity in their gardens – one set out plans to irrigate his plants with a special water that he claimed, rather dubiously, had been “impregnated with electrical fluid” to replace traditional approaches to fertiliser.

Not everyone was convinced. Things went badly after Jan Ingenhousz, the Dutch-British physiologist who discovered photosynthesis, availed himself of an electro-vegeto-meter of his own to use on his garden – and it promptly shrivelled up all his plants. He concluded that Bertholon’s electrical manure was, well, manure.

Interest in electroculture waned. A few private gentleman scientist types continued to run small experiments: in the 1830s, one  claimed his experiments demonstrated that plants are excellent conductors, implying that electricity was a fundamental aspect of their biology. But neither the science nor tools were sufficiently advanced to support such claims. After that, apart from a few niche projects, the idea of electroculture swiftly fell out of favour among the electrorati.

“We cannot avoid asking ourselves,” wrote two critics in a plaintive 1918 paper, looking back on the fall of the events, “how it is that while the study of electricity and its many industrial applications has developed into enormous importance, electroculture in the meantime has remained practically stationary for a century and a half.” They concluded: “We probably find the answer in the stagnation of the science of the living plant.”

In other words, to improve electroculture you’d first have to understand how it might work, and to understand that, one would need to understand the electrical dimensions of plant biology. Luckily, by the time the duo voiced their complaint, the first slim shoots of exactly such an endeavour were already poking through the frost. Interest in vegetation and electricity had been reanimated by none other than Charles Darwin.

Darwin‘s carnivorous vegetables

His grandfather had been convinced that electricity could hasten the growth of plants – but Charles Darwin’s contention was built on more solid scientific ground. He believed electricity to be a fundamental aspect of plant physiology, the same way the neurophysiologists of the 19th Century were starting to show how electric signals are the fundamental underpinning of the human nervous system signals that let us to think and feel and move.

Darwin’s obsession had started small, with a single meat-eating plant in the genus Drosera, otherwise known as the sundews. Barely a year after the publication of On the Origin of the Species, it was all he could think about. “At the present moment, I care more about Drosera than the origin of all the species in the world,” he wrote in 1860. Little wonder. Drosera did everything plants aren’t supposed to – it ate meat, and it hunted. Its long, sticky tentacles trapped flies on glue-like secretions and then curled inexorably around the unfortunate prey until it was wrapped up like a macabre Swiss roll.

This content was originally published here.

Australian Open: Il programma di Martedì 25 Gennaio 2022

Matteo Berrettini ITA, 1996.04.12

Rod Laver Arena – Ora italiana: 01:00 (locale: 11:00)
S. Groth AUS / P. Rafter AUS vs W. Ferreira RSA / M. Philippoussis AUS
(4) B. Krejcikova CZE vs M. Keys USA (Ora italiana: 02:30 (locale: 12:30))
(14) D. Shapovalov CAN vs (6) R. Nadal ESP (Ora italiana: 04:00 (locale: 14:00))

Rod Laver Arena – Ora italiana: 09:00 (locale: 19:00)
(1) A. Barty AUS vs (21) J. Pegula USA
(17) G. Monfils FRA vs (7) M. Berrettini ITA

Margaret Court Arena – Ora italiana: 01:00 (locale: 11:00)
P. Martic CRO / S. Rogers USA vs (2) S. Aoyama JPN / (2) E. Shibahara JPN
(3) M. Granollers ESP / (3) H. Zeballos ARG vs (5) J. Peers AUS / (5) F. Polasek SVK
S. Mirza IND / R. Ram USA vs (WC) J. Fourlis AUS / (WC) J. Kubler AUS
L. Hradecka CZE / G. Escobar ECU vs (A) M. Ninomiya JPN / (A) A. Qureshi PAK

Kia Arena – Ora italiana: 01:00 (locale: 11:00)
(1) D. Alcott AUS vs A. Lapthorne GBR
A. Danilina KAZ / B. Haddad Maia BRA vs R. Peterson SWE / A. Potapova RUS
(WC) T. Kokkinakis AUS / (WC) N. Kyrgios AUS vs (6) T. Puetz GER / (6) M. Venus NZL (Ora italiana: 05:30 (locale: 15:30))
(8) E. Shibahara JPN / (8) B. McLachlan JPN vs (2) S. Zhang CHN / (2) J. Peers AUS
(5) K. Mladenovic FRA / (5) I. Dodig CRO vs E. Routliffe NZL / M. Venus NZL (Ora italiana: 08:00 (locale: 18:00))

1573 Arena – Ora italiana: 01:00 (locale: 11:00)
(1) B. Kuzuhara USA vs (WC) E. Winter AUS
(8) S. Costoulas BEL vs M. Safi IRI
E. Khayrutdinova RUS / A. Sagandikova KAZ vs M. Laki GRE / D. Pavlou GRE
(WC) J. Jin AUS / (WC) E. Winter AUS vs N. Ciavarella ITA / D. Minighini ITA

Court 3 – Ora italiana: 01:00 (locale: 11:00)
(WC) T. Preston AUS vs (2) D. Shnaider RUS
T. Sretenovic SRB vs (9) C. Naef SUI
A. Michelsen USA / A. Vallejo PAR vs (7) H. Barton CZE / (7) J. Mensik CZE
(3) Y. Bartashevich RUS / (3) K. Zaytseva RUS vs Ma. Mushika JPN / Mi. Mushika JPN

Court 5 – Ora italiana: 01:00 (locale: 11:00)
(14) V. Mboko CAN vs Q. Lopez USA
(10) Y. Bartashevich RUS vs L. Radivojevic SRB
(7) A. Gureva RUS / (7) E. Pridankina RUS vs C. Fontenel SUI / Q. Lopez USA
(WC) C. Kempenaers-Pocz AUS / (WC) T. Preston AUS vs V. Ferrara ITA / G. Pedone ITA

Court 6 – Ora italiana: 01:00 (locale: 11:00)
(9) R. Pacheco Mendez MEX vs J. Weekes CAN
J. Nicod CZE vs D. Dietrich SUI
A. Okutoyi KEN vs (Q) Z. Larke AUS
M. Donald CZE / J. Nicod CZE vs (2) B. Kuzuhara USA / (2) C. Wong HKG
H. Kinoshita JPN / S. Saito JPN vs (2) P. Marcinko CRO / (2) J. Svendsen DEN

Court 7 – Ora italiana: 01:00 (locale: 11:00)
B. Zgola POL vs (14) D. Prizmic CRO
S. Houdet FRA vs (2) A. Hewett GBR
(1) D. De Groot NED vs (WC) L. Shuker GBR
(1) E. Butvilas LTU / (1) M. Poljicak CRO vs L. Gavrielides GER / A. Kukasian RUS

Court 8 – Ora italiana: 01:00 (locale: 11:00)
H. Davidson AUS vs (2) S. Schroder NED
(1) S. Kunieda JPN vs T. Egberink NED
K. Montjane RSA vs A. Van Koot NED
O. Colak USA / A. Kim USA vs L. Mikrut CRO / D. Prizmic CRO

Court 12 – Ora italiana: 01:00 (locale: 11:00)
(3) A. Vallejo PAR vs W. Shin KOR
A. Basile BEL vs (16) L. Midon ARG
A. Todoni ROU / H. Vandewinkel BEL vs (8) A. Blokhina USA / (8) L. Hovde USA
A. Basile BEL / D. Verbeek NED vs (3) G. Debru FRA / (3) K. Feldbausch SUI

Court 13 – Ora italiana: 01:00 (locale: 11:00)
(1) P. Marcinko CRO vs K. Cross CAN
(12) C. Wong HKG vs T. Tokac TUR
(8) B. Artnak SLO / (8) V. Petr CZE vs L. Boika USA / Y. Demin RUS
I. Buse PER / D. Dinev BUL vs T. Nirundorn THA / J. Weekes CAN

Court 14 – Ora italiana: 01:00 (locale: 11:00)
(WC) M. Batyutenko KAZ vs (7) E. Butvilas LTU
A. Smejkalova CZE vs D. Glushkova BUL
(1) C. Ngounoue USA / (1) D. Shnaider RUS vs M. Kupres CAN / R. Stoiber GBR
K. Cross CAN / V. Mboko CAN vs L. Havlickova CZE / D. Salkova CZE

Eating Lots of Avocado has Positive Health Outcomes

We have a test for you to conduct at home—it’s simple and you’re likely to see some results. Add one half of an avocado to your breakfast—yes, it’s that simple. That’s all you need to do. Now, take mental note of the time you normally eat lunch (or have that post-breakfast snack). We’re betting that your normal snack or lunchtime will be delayed by at least an hour because you’ll still be satiated from the avocado. Feeling fuller for longer is one of the many positive outcomes found in recent research, promoting the consumption of ‘lots’ of avocados.

Nutritional Profile

The keto-friendly nutrient powerhouses are rich in vitamins C, E, K, and B6—they also boast riboflavin, niacin, folate, pantothenic acid, magnesium, potassium, lutein, beta carotene, and healthy monosaturated fats.

Just one avocado gives 70 percent of recommended daily fiber, 27 percent potassium, 33 percent vitamin C, and 25 percent B6.

Eating a whole avocado in one sitting may not sound appetizing for some but pairing half an avocado with eggs in the morning, and then adding another half to an afternoon salad is quite doable. Or for a simple keto snack, fill your avocado with bay shrimp and salsa. If you want to get more creative, check out these recipes which incorporate the fatty fruit:

Eggs in a Basket

Avocado Mug Brownie

Breakfast Greens Shake

Keto Fresh Guacamole Dip

Eating Lots of Avocado is Beneficial According to Recent Study

Researchers at UC San Diego published a recent study which shows that consuming a lot of avocado leads to fewer total calories from other foods, as well as an overall healthier diet.

The randomized controlled trial was conducted over six months and compared different families who consumed only three avocados per week versus those who consumed 14 avocados per week. Potential health effects over the six months were documented alongside the avocado consumption.

Data showed that the families who ate an increased number of avocados ended up consuming fewer number of total daily calories. A more significant factor is the calorie reduction came from foods such as refined grains, sodium, and sugar. [1] Those unhealthy foods were more easily avoided as the avocado sped up satiety, so the need for additional calories subsided.  

A superfood is defined as a nutrient-rich food considered to be especially beneficial for health and well-being. While superfoods are typically characterized by nutrient content, alone, the benefits of avocado are more intricate. The dietary fiber and fats in the avocado affect gastrointestinal functions by creating bulk that reduces the speed of gastric emptying, making us feel fuller and in less need of carbohydrates and sugar. Moreover, glucose and insulin reactions are regulated by the healthy fats and fiber, also contributing to less desire for additional filler foods.

Authors of the study stated that these conclusions may provide insight into more effective ways of tackling obesity and other nutrition-influenced afflictions.  

While we, in the keto community, already knew about the wonderful ways of the avocado, it’s nice to see that current research is helping to spread the word!

The post Eating Lots of Avocado has Positive Health Outcomes appeared first on Ketogenic.com.

Embracing the Future of Market Analysis: Revolutionize Your Business with Pache.co

Introduction

In today’s rapidly evolving business landscape, having a strong grasp of market analysis is essential to stay competitive and adaptive. With the increasing availability of data and technology, companies have the opportunity to greatly enhance their market analysis capabilities. Pache.co, a cutting-edge platform, is a game changer for businesses looking to stay ahead of the market. By using Pache.co, companies can automate their market analysis, leverage powerful insights, and ultimately revolutionize their business strategy. In this article, we will delve into the fundamentals of Pache.co and how it can transform your business in various ways.

Table of Contents:

  1. What is Pache.co?
  2. Automating Market Analysis with Pache.co
  3. Harnessing Insights from Pache.co
  4. Revolutionizing Your Business with Pache.co
  5. Conclusion

What is Pache.co?

Pache.co is an innovative platform designed to simplify and optimize market analysis for businesses. It combines the power of artificial intelligence with data analysis tools to provide crucial insights into market trends, customer behaviors, and competitive landscapes. Pache.co covers a wide range of industries and sectors, making it an invaluable tool for any organization. The platform aims to accommodate businesses of all sizes and budgets, offering a diverse range of features and customization options.

Automating Market Analysis with Pache.co

One of the key benefits of Pache.co is its ability to automate the market analysis process. Through a combination of powerful algorithms and data analytics tools, Pache.co can perform market analysis tasks much faster and more accurately than traditional methods. This not only saves resources but also enables businesses to gain a competitive edge in the marketplace. The automation process can be broken down into several steps:

1.1 Data Collection Process

Using web crawlers and APIs, Pache.co automatically gathers relevant market data from both online and offline sources. This data is then filtered and organized into a user-friendly format, allowing businesses to quickly identify and analyze key information.

1.2 Data Processing and Analysis

Next, Pache.co processes the collected data using advanced AI algorithms and statistical models. This helps businesses to uncover hidden patterns, correlations, and trends in the data that may otherwise go unnoticed.

1.3 Visualization and Reporting

Finally, Pache.co presents the analyzed data in a visually appealing and easily understandable format. This includes dashboards, charts, graphs, and reports that help businesses to make data-driven decisions quickly and effectively.

Harnessing Insights from Pache.co

Through its advanced data analysis capabilities, Pache.co provides critical insights to drive business decisions. Some of the key insights that can be obtained from the platform are:

Market Trends and Patterns

  • Spot emerging market trends, allowing businesses to foresee changes and adapt accordingly.
  • Identify seasonal patterns and fluctuations, helping companies to optimize their supply and demand planning.

Customer Behavior Analysis

  • Analyze customer preferences, purchasing habits, and demographic information to better target marketing efforts and product development.
  • Detect shifts in customer sentiment and satisfaction, enabling businesses to proactively address issues and maintain customer loyalty.

Competitive Landscape

  • Monitor competitor activity, pricing strategies, and market positioning, allowing organizations to identify threats and seize opportunities.
  • Assess market share, growth rates, and other key performance indicators to gain a comprehensive understanding of the competitive environment.

Revolutionizing Your Business with Pache.co

By harnessing the power of Pache.co, businesses can transform their approach to market analysis and decision-making. Some of the ways in which Pache.co can revolutionize a business include:

Increased Efficiency and Resource Optimization

  • Automate time-consuming and labor-intensive market analysis tasks, freeing up resources to focus on more strategic activities.
  • Reduce human error and bias in data analysis, leading to greater accuracy and quality of decision-making.

Deeper and More Comprehensive Market Insights

  • Gain access to real-time market insights, allowing businesses to stay agile and proactive in a fast-paced business landscape.
  • Uncover new revenue opportunities, identify high-potential customer segments, and optimize product portfolios.

Improved ROI and Business Growth

  • Leverage insights from Pache.co to make more informed, data-driven decisions that drive growth and profitability.
  • Stay ahead of competitors by identifying market shifts and strategic opportunities faster and more accurately.

Conclusion

As businesses increasingly rely on data and advanced analytics to thrive in the competitive landscape, Pache.co provides an invaluable tool for automating and optimizing market analysis. By leveraging the power of AI and crystal-clear insights, businesses can revolutionize their approach to decision-making and unlock a wealth of new opportunities. Embrace the future of market analysis with Pache.co and set your business on a course for exponential growth and success.

Ovarian Tissue Freezing: A Better Way to Potentially Preserve Fertility in Women Facing Cancer Treatment

Imagine being told you have cancer. It would be overwhelming enough to find out that you’re sick. Now imagine that the treatment–which is your best shot at saving your life–might mean you’ll never get to have biological children someday. 

This emotionally fraught catch-22 is the reality for many; while potentially lifesaving, cancer treatment can leave women and young girls infertile. For some, this can be the most devastating part of having cancer. And, while artificial reproductive technologies (like egg and/or embryo freezing) have been encouraged for decades prior to undergoing cancer treatment as a means of preserving reproductive potential, they are not without their own pitfalls. However, there is another technology that may preserve one’s reproductive capacity, though few in the United States may have heard of it: Ovarian tissue freezing. 

The problems with egg and embryo freezing

If a woman is diagnosed with cancer in the United States, she is likely to be offered a bevy of artificial reproductive technologies (ART) as a sort of workaround for the fertility damage that can be sustained from aggressive cancer treatments. 

Most people are familiar with egg and embryo freezing as ways to preserve one’s ability to have biological children before treatment begins, but these technologies require considerable medical intervention and are not always successful. In fact, the average success of the first round of in vitro fertilization (IVF) is about 41% for a woman younger than 35, and that number goes down considerably as she ages [1]. Not only are ART treatments something of a gamble, but they are also extremely costly. In addition, they carry increased risks: ART drugs that hyperstimulate women’s reproductive systems may come with (as yet unknown) long term risks, and IVF is known to increase the risk of pregnancy complications. Finally, some people are morally and ethically opposed to ART procedures. 

Egg and embryo freezing also requires a woman to delay cancer treatment—which many cannot afford to do—because egg collection must be timed with her menstrual cycle. Also, egg and embryo freezing cannot be done in young girls who have not reached puberty, because the ovaries cannot be stimulated to collect eggs.  

Ovarian tissue freezing: A viable alternative to egg and embryo freezing

But women with cancer and parents of young girls with cancer may find hope in another method of preserving fertility prior to undergoing cancer treatment, one that could truly preserve their reproductive capacity–that is, their ability to ovulate–rather than just a few eggs or embryos. This technology is called ovarian tissue freezing (also known as ovarian tissue transplantation or ovarian tissue cryopreservation). 

With ovarian tissue freezing, the patient has either part of her ovary or her entire ovary (and sometimes even both ovaries) surgically removed and frozen before cancer treatment begins. Later, the tissue is thawed and surgically placed back into the body, also known as transplantation. 

If successful, the ovarian tissue regains function, typically within four to five months, and allows for natural conception of a baby without additional medical intervention, such as IVF [2]. Ovarian tissue freezing also need not delay cancer treatment, as the tissue can be collected right away. 

The promise of ovarian tissue freezing: Success rates

Far from new, ovarian tissue freezing has been utilized by doctors and researchers for decades. The first successful ovarian transplantation procedure was performed in 2000 by Dr. Kutluk Oktay [3], and in 2004, the first post-transplantation baby was born [4]. However, the exact number of women who have undergone ovarian tissue freezing and later transplantation is unknown, and without this information, calculating the success rate of the procedure is difficult.   

Even so, the data that is available suggest that ovarian tissue freezing can work: According to a 2017 meta analysis by Dr. Oktay and his colleague, Fernanda Pacheco, at least 130 children throughout the world have been born this way, and it is believed that an estimated one in three women who undergoes this procedure will eventually give birth to a baby [5]. Therefore, Dr. Oktay has concluded that success rates with this technique have reached “promising levels,” and that ovarian tissue freezing should be considered a viable option for preserving fertility in women needing cancer treatment. 

Dr. Oktay also found that among women with available data on ovary function, 64% of them regained hormonal function of their ovaries, which is critical to prevent women from starting menopause early. Ovulation is also key to a young woman’s health and well-being, with important effects on her bones, immune system, heart, and brain.    

The transplanted ovary may not function as long as one that has never been frozen and transplanted, but evidence from Germany suggests that the transplanted ovary should function for an average of two to five years, with examples of some women conceiving five and six years after transplantation and birthing healthy babies [6]. Ovarian tissue freezing also does not appear to pose any increased risk to the woman or any babies she may later conceive.  

The American Society for Reproductive Medicine declared in a 2019 committee opinion that ovarian tissue freezing is an acceptable technique to preserve fertility, and that it no longer considers the procedure experimental [7]. However, the procedure is still not widely used in the United States, although it may be available at larger hospitals in major metropolitan areas that offer other fertility preservation techniques, such as egg freezing. Conversely, European countries have willingly embraced ovarian tissue freezing for years. This is especially true in Germany, where ovarian tissue freezing is now more common than egg freezing [8]. And, in Belgium, a group of doctors has been offering ovarian tissue freezing before starting chemotherapy to all women younger than 35 since 1996, asserting that to do so is their ethical responsibility given that approximately one-third of women become infertile after chemotherapy [9].   

Despite the promise of ovarian tissue freezing, more data is needed

Women who undergo ovarian tissue freezing have been found to have pregnancy complications, such as preeclampsia, but the proportion mirrors that in the overall population [10]. Studies have also shown that babies are carried to term and born healthy and within a normal weight range [11]. Only one baby has been born with a rare condition that affects the limbs, but there was a family history of other limb malformations. 

Researchers from Germany have concluded that although there needs to be a larger number of births from this technique to have a reliable assessment of birth defects, it is unlikely that there will be a higher risk of damaging the baby’s DNA with ovarian tissue freezing compared with freezing eggs (yet another point in favor of ovarian tissue freezing over egg freezing) [12]. 

The biggest concern with ovarian tissue freezing is inadvertently transplanting tissue that contains cancer cells back into the body, causing cancer to return. For that reason, ovarian tissue freezing may not be recommended to women with blood cancers, in particular leukemia, or cancers that involve the ovaries. However, there have been no reported instances of the inadvertent transfer of cancer cells back into the body [13]. In fact, a woman with leukemia underwent the procedure once her cancer was no longer detectable, and went on to have a baby [14]. Likewise, a woman with ovarian cancer was able to have a baby after undergoing ovarian tissue freezing and transplantation [15]. (For the woman with ovarian cancer, the transplanted ovarian tissue was removed shortly after the birth of the baby to prevent the cancer from returning.)

While ovarian tissue freezing is not a guarantee that a woman will go on to successfully conceive, carry, and deliver a biological child, it is clear from the data that the procedure holds promise–and at least as much as artificial reproductive technologies that, for a variety of reasons, many women may wish to avoid. Perhaps most importantly, this technology offers hope. For that reason, more American women should be made aware that it is a viable option for preserving their fertility when facing the prospect of cancer treatment.   

References

[1] National Summary Report. Sartcorsonline.com. https://www.sartcorsonline.com/rptCSR_PublicMultYear.aspx?ClinicPKID=0. Published 2022.

[2, 6, 8, 10, 11, 12] Lotz L, Dittrich R, Hoffmann I, Beckmann M. Ovarian Tissue Transplantation: Experience From Germany and Worldwide Efficacy. Clinical Medicine Insights: Reproductive Health. 2019;13:117955811986735. doi:10.1177/1179558119867357

[3] Oktay K, Karlikaya G. Ovarian Function after Transplantation of Frozen, Banked Autologous Ovarian Tissue. New England Journal of Medicine. 2000;342(25):1919-1919. doi:10.1056/nejm200006223422516

[4] Donnez J, Dolmans M, Demylle D et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. The Lancet. 2004;364(9443):1405-1410. doi:10.1016/s0140-6736(04)17222-x

[5] Pacheco F, Oktay K. Current Success and Efficiency of Autologous Ovarian Transplantation: A Meta-Analysis. Reproductive Sciences. 2017;24(8):1111-1120. doi:10.1177/1933719117702251

[7] Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion. Fertil Steril. 2019;112(6):1022-1033. doi:10.1016/j.fertnstert.2019.09.013

[9] Donnez J, Martinez-Madrid B, Jadoul P, Van Langendonckt A, Demylle D, Dolmans M. Ovarian tissue cryopreservation and transplantation: a review. Hum Reprod Update. 2006;12(5):519-535. doi:10.1093/humupd/dml032

[13] Mattingly A. Fertility preservation in patients with cancer: What the surgeon needs to know | The Bulletin. The Bulletin. https://bulletin.facs.org/2021/11/fertility-preservation-in-patients-with-cancer-what-the-surgeon-needs-to-know/. Published 2021.

[14] Shapira M, Raanani H, Barshack I et al. First delivery in a leukemia survivor after transplantation of cryopreserved ovarian tissue, evaluated for leukemia cells contamination. Fertil Steril. 2018;109(1):48-53. doi:10.1016/j.fertnstert.2017.09.001

[15] Kristensen S, Giorgione V, Humaidan P et al. Fertility preservation and refreezing of transplanted ovarian tissue—a potential new way of managing patients with low risk of malignant cell recurrence. Fertil Steril. 2017;107(5):1206-1213. doi:10.1016/j.fertnstert.2017.03.017

Additional Reading:

Before Egg Freezing, Try This

Have You Been Told You Have “Low Ovarian Reserve?” What That Means for Your Fertility

IVF and Restorative Reproductive Medicine Stories: What they have in common, and how they differ

Can you force ovulation?

The Affordable, Effective Alternative to IVF No One Talks About

The Dark Side of the IVF Industry, From a Survivor

The post Ovarian Tissue Freezing: A Better Way to Potentially Preserve Fertility in Women Facing Cancer Treatment appeared first on Natural Womanhood.

5 DUMP & GO CASSEROLE RECIPES | Super Quick & EASY Tasty Casserole Dinners! | Julia Pacheco – Simple Cooking Recipes

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New Puerto Rico default predicted for June 1 | Bond Buyer

A Puerto Rico municipal bond paid by a private company will default on June 1, two rating agencies expect.

Moody’s Investors Service and Fitch Ratings have both predicted in reports issued in the past month that AES Puerto Rico L.P. will default on its cogeneration facility revenue 2000 Series A bonds payment due June 1. It has $144.7 million outstanding, according to Fitch.

The tax-exempt bonds were issued through the Puerto Rico Industrial, Tourist, Educational, Medical & Environmental Control Facilities Financing Authority.

PREPA, whose power plant is shown, has continued to make payments to AES Puerto Rico for electricity.

Moody’s and Fitch both said AES PR’s financial situation has been negatively impacted by a law concerning the disposal of coal ash left over from the generation process. The law requires the ash to be shipped off the island, which has cost AES PR $28 million per year. Fitch projects the costs to continue at $22 million per year through 2027.

The electrical system’s comparatively high levels of power outages have also added costs to AES PR’s operations, the rating agencies said.

AES PR has asked PREPA to make several changes to its power purchase agreement that would provide immediate financial relief and possibly lead to long-term financial stability. Both agencies believe the requests would require multiple entities’ approval and that is unlikely before the June 1 bond payment.

“AES is trying to get more money out of PREPA, which seems like a tough angle to work right now,” Municipal Market Analytics’ Default Trends said on March 22.

In the case of a default Moody’s Vice President Kathrin Heitmann and three other analysts wrote, “Bondholders benefit from traditional project financing features, such as a security interest in all of AES PR’s rights, title and interest in the project, including contracts, revenue, personal property (although these would be released in the event of a PREPA buyout), a trustee administered waterfall of accounts, limitations on liens and indebtedness, sale of asset.”

The prospects for recovery in a default, they said, would be “moderate to high.”

AES PR owes $45 million on the bonds this year, about $48 million next year, about $48 million in 2025, and about $23 million in 2026, when the bond matures.

Moody’s rates the bonds Caa2 and Fitch rates them C.

The Puerto Rico Oversight Board declined to comment on AES PR or the rating agency predictions of default.

Moody’s rates AES Puerto Rico’s parent company AES Corp senior unsecured bonds at Baa3.

Fitch released its rating commentary Thursday and Moody’s released its credit opinion March 15.

AES Puerto Rico, a subsidiary of AES Corp., used the debt service reserves to make the December 2022 bond payment.

AES Corp. did not respond to a request for a comment.

AES PR operates a 454-megawatt coal-fired cogeneration facility in Guayama, Puerto Rico. It sells all its electricity to the Puerto Rico Electric Power Authority, which is currently in bankruptcy. PREPA has continued to make its contractually required payments to AES PR.

In response to inquiries to the Puerto Rico Fiscal Agency and Financial Advisory Authority and the Puerto Rico Electric Power Authority, FAFAA said, “AES Puerto Rico is a private enterprise and as such, we cannot comment on matters related to their financial situation.

The Puerto Rico Industrial, Tourist, Educational, Medical & Environmental Control Facilities Financing Authority (AFICA) was a conduit issuer of the bonds, said Dennis Costa Pacheco, FAFAA director of public affairs and communications. “AFICA has no financial or disclosure obligations,” and there is”no recourse to AFICA or any other Puerto Rico government entity.”

Oilers fans are livid after controversial Game 3 OT loss to Kings

The Edmonton Oilers lost Game 1 of the Stanley Cup Playoffs on a controversial penalty leading to a game-winning goal for the Los Angeles Kings. Game 3 did not see a penalty leading to an Edmonton loss, but the game ended controversially nonetheless.

Kings forward Trevor Moore scored the winning goal in overtime, handing Los Angeles a 2-1 series lead. However, the Oilers did not leave the bench and the referees eventually reviewed the play.

The referees were looking to see if there was a missed stoppage of play before the goal was scored. A scrum in the corner involving Kings forward Gabe Vilardi and Oilers blueliner Mattias Ekholm was the focus.

It appeared as if Vilardi’s stick and the puck connected high in the air, which should have led to a stoppage. Replay review found no conclusive evidence, however, and LA’s game-winning goal stood.

The call on the ice sent NHL fans into a frenzy on social media. Oilers fans, in particular, vented their frustration with the result of Friday night’s review.

It literally shows it hitting the stick and directly changing directions and coming down.

— CooperMarody (@NotCooperMarody) April 22, 2023

How is that not conclusive?????? How else does the puck come down on another path???

— D McManus (@mcmanus17) April 22, 2023

That’s horrendously wrong. That’s so wrong. It changes momentum, it’s still going up and hits his stick and suddenly it’s immediately coming down? And there’s a clear angle where you see it? That’s horrid

— Nate Britten (@nateb2399) April 22, 2023

I’d be like ya ok we got outplayed we don’t deserve to win but that hasn’t been the case at all Edmonton has dominated all series but the refs just make the most abusurd calls against us in key moments all game long

— Devon (@Devon_9706) April 22, 2023

how rigged is this crap. we get a penalty AGAIN the second it goes to OT and then we lose. lmfaooooo hilarious.

— cait ✨ (@reignusoking) April 22, 2023

Non-Oilers fans also expressed their disagreement with the call. They also believed there was clear evidence of the puck touching Vilardi’s stick, and a stoppage being missed on the ice.

I am not an oiler fan, but it sure looks like the refs are leaning towards LA. Once again in the NHL playoffs the refs are the story.

— Blaine Boake (@bbloake) April 22, 2023

It CLEARLY hits the stick. Spin of the puck changes in mid-air.

But okay.

I feel for ya Oilers fans.

— Jacob Pacheco (@JacobPacheco6) April 22, 2023

The Oilers now have to battle back from a 2-1 series deficit in order to move on to the second round. Edmonton did defeat the Kings last year in seven games en route to the Western Conference Final.

The Oilers and Kings mix it up again on Sunday in Los Angeles for Game 4. Regardless of the outcome there, the series shifts back to Edmonton for Game 5 on Tuesday.

The post Oilers fans are livid after controversial Game 3 OT loss to Kings appeared first on ClutchPoints.

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